|
|
dehydroepiandrosterone_3-sulfate + H2O <=> dehydroepiandrosterone + sulfate + H+
|
3.1.6.1
arylsulfatase
3.1.6.2
steryl-sulfatase
3.1.6.8
cerebroside-sulfatase
|
–
–
–
|
K
|
|
BRENDA:
BR15971
KEGG:
R03404
MetaCyc:
STERYL-SULFATASE-RXN
|
|
|
|
dehydroepiandrosterone + NAD+ <=> 5-androstene-3,17-dione + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
|
MK
|
|
BRENDA:
BS257032
KEGG:
R09957
MetaCyc:
RXN66-342
SABIO-RK:
7900
|
|
|
|
3''-phosphoadenylyl-sulfate + dehydroepiandrosterone <=> adenosine_3,5''-bisphosphate + dehydroepiandrosterone_3-sulfate + H+
|
2.8.2.1
aryl sulfotransferase
2.8.2.14
bile-salt sulfotransferase
2.8.2.15
steroid sulfotransferase
2.8.2.2
alcohol sulfotransferase
2.8.2.34
glycochenodeoxycholate sulfotransferase
2.8.2.4
estrone sulfotransferase
|
–
–
–
–
–
–
|
K
|
|
BRENDA:
BS360111
KEGG:
R03405
MetaCyc:
RXN-20214
SABIO-RK:
9168
|
|
|
|
17alpha-hydroxypregnenolone + reduced_flavodoxin + O2 <=> dehydroepiandrosterone + acetate + flavin + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
K
|
|
BRENDA:
BR51745
KEGG:
R08517
|
|
|
|
androstenediol + NADP+ <=> dehydroepiandrosterone + NADPH
|
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
1.1.1.64
testosterone 17beta-dehydrogenase (NADP+)
|
–
–
–
|
K
|
|
BRENDA:
BS188301
KEGG:
R03407
SABIO-RK:
3210
|
|
|
|
androstenediol + NAD+ <=> dehydroepiandrosterone + NADH
|
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
|
K
|
|
BRENDA:
BS188505
KEGG:
R03406
SABIO-RK:
3209
|
|
|
|
dehydroepiandrosterone + NAD+ <=> 4-androstene-3,17-dione + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
5.3.3.1
steroid Delta-isomerase
|
–
–
–
|
K
|
|
BRENDA:
BS403792
KEGG:
R01837
|
|
|
|
4-androstene-3,17-dione + NADPH + H+ <=> dehydroepiandrosterone + NADP+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
|
|
BRENDA:
BS257049
SABIO-RK:
1918
|
|
|
|
dehydroepiandrosterone + UDP-glucose <=> UDP + dehydroepiandrosterone_3-beta-D-glucoside
|
2.4.1.173
sterol 3beta-glucosyltransferase
2.4.1.192
nuatigenin 3beta-glucosyltransferase
|
–
–
|
|
|
BRENDA:
BS322412
SABIO-RK:
10333
|
|
|
|
dehydroepiandrosterone + NADP+ <=> 5-androstene-3,17-dione + NADPH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.146
11beta-hydroxysteroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
–
|
|
|
BRENDA:
BS395992
SABIO-RK:
7901
|
|
|
|
dehydroepiandrosterone + H+ + O2 + NADPH <=> 16alpha-hydroxy-dehydroepiandrosterone + NADP+ + H2O
|
1.14.13
1.14.14.1
unspecific monooxygenase
|
–
–
|
K
|
|
KEGG:
R03408
|
|
|
|
dehydroepiandrosterone + O2 + reduced_flavodoxin <=> 7alpha-hydroxydehydroepiandrosterone + flavin + H2O
|
1.14.14.23
cholesterol 7alpha-monooxygenase
|
–
|
K
|
|
KEGG:
R08961
|
|
|
|
androsterone + NADP+ <=> dehydroepiandrosterone + NADPH + H+
|
1.3.1
|
–
|
|
|
MetaCyc:
RXN-12742
|
|
|
|
17alpha-hydroxypregnenolone + reduced_[NADPH-hemoprotein_reductase] + O2 <=> dehydroepiandrosterone + acetate + oxidized_[NADPH-hemoprotein_reductase] + H2O + H+
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
M
|
|
MetaCyc:
RXN66-341
|
|
|
|
dehydroepiandrosterone + O2 <=> 5-androstene-3,17-dione + H2O2
|
1.1.3.6
cholesterol oxidase
|
–
|
|
|
BRENDA:
BS188846
|
|
|
|
17alpha-hydroxyprogesterone + reduced_acceptor + O2 <=> dehydroepiandrosterone + 4-androstene-3,17-dione + A + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
|
BRENDA:
BS416054
|
|
|
|
dehydroepiandrosterone + reduced_adrenodoxin + O2 <=> 7beta-hydroxydehydroepiandrosterone + oxidized_ferredoxin + H2O
|
1.14.15.8
steroid 15beta-monooxygenase
|
–
|
|
|
BRENDA:
BS443452
|
|
|
|
dehydroepiandrosterone + NADH + H+ + O2 <=> 3beta,9alpha-dihydroxy-5-androstene-17-one + 2 oxidized_ferredoxin + H2O
|
1.14.15.30
3-ketosteroid 9alpha-monooxygenase
|
–
|
|
|
BRENDA:
BS443451
|
|
|
|
dehydroandrosterone_3-sulfate + H2O <=> dehydroepiandrosterone + sulfate
|
3.1.6.2
steryl-sulfatase
|
–
|
|
|
BRENDA:
BS93851
|
|
|
|
dehydroepiandrosterone <=> androst-4-ene-3beta-ol-17-one
|
5.3.3.1
steroid Delta-isomerase
|
–
|
|
|
BRENDA:
BS368679
|
|
|
|
dehydroepiandrosterone + NADH + H+ <=> androsterone + NAD+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
|
|
BRENDA:
BS370927
|
|
|
|
5-androstene-3,17-dione + NAD+ <=> dehydroepiandrosterone + NADH + H+
|
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
|
–
|
|
|
BRENDA:
BS425797
|
|
|
|
17alpha-hydroxypregnenolone + reduced_flavodoxin + O2 <=> dehydroepiandrosterone + acetate + flavin + H2
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
|
BRENDA:
BS436714
|
|
|
|
7alpha-hydroxypregnenolone + reduced_flavodoxin + O2 <=> dehydroepiandrosterone + acetate + flavin + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
|
BRENDA:
BS398630
|
|
|
|
pregnenolone + reduced_flavodoxin + O2 <=> dehydroepiandrosterone + acetate + flavin + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
|
BRENDA:
BS443860
|
|
|
|
17alpha-hydroxypregnenolone + reduced_acceptor + O2 <=> dehydroepiandrosterone + acetate + A + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
|
BRENDA:
BS415535
|
|
|
|
dehydroepiandrosterone + O2 <=> 5-androstene-3,17-dione + H2O
|
1.1.3.6
cholesterol oxidase
|
–
|
|
|
BRENDA:
BS373029
|
|
|
|
dehydroepiandrosterone + NADPH + H+ + O2 <=> 7alpha-hydroxydehydroepiandrosterone
|
1.14.14.29
25/26-hydroxycholesterol 7alpha-hydroxylase
|
–
|
|
|
BRENDA:
BS396974
|
|
|
|
dehydroepiandrosterone + NADPH + H+ + O2 <=> 7alpha-hydroxydehydroepiandrosterone + NADP+ + H2O
|
1.14.14.29
25/26-hydroxycholesterol 7alpha-hydroxylase
|
–
|
|
|
BRENDA:
BS376660
|
|
|
|
dehydroepiandrosterone + NADPH <=> dehydroepiandrosterone + NADP+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
|
|
BRENDA:
BS257050
|
|
|
|
dehydroepiandrosterone + NADPH <=> 5-androstene-3alpha,17alpha-diol + NADP+
|
1.1.1.148
estradiol 17alpha-dehydrogenase
|
–
|
|
|
BRENDA:
BS384577
|
|
|
|
dehydroepiandrosterone + NADPH <=> androstene-3beta,17beta-diol + NADP+
|
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
|
|
|
BRENDA:
BS388508
|
|
|
|
3''-phosphoadenylylsulfate + dehydroepiandrosterone <=> adenosine_3'',5''-bisphosphate + androst-5-en-17-one_3-sulfate
|
2.8.2.14
bile-salt sulfotransferase
2.8.2.15
steroid sulfotransferase
2.8.2.2
alcohol sulfotransferase
|
–
–
–
|
|
|
BRENDA:
BS378389
|
|
|
|
dehydroepiandrosterone_oleate + H2O <=> dehydroepiandrosterone + oleic_acid
|
3.1.1.79
hormone-sensitive lipase
|
–
|
|
|
BRENDA:
BS373028
|
|
|
|
17alpha-hydroxypregnenolone <=> dehydroepiandrosterone + acetaldehyde
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
|
BRENDA:
BS1752
|
|
|
|
dehydroepiandrosterone <=> 4-androstene-3,17-dione
|
5.3.3.1
steroid Delta-isomerase
|
–
|
|
|
BRENDA:
BS428561
|
|
|
|
NADPH + 17alpha-hydroxypregnenolone <=> dehydroepiandrosterone + NADP+
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
|
|
SABIO-RK:
7634
|
|